Eva Pontén

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About me

I am a hand surgeon and a pediatric orthopaedic surgeon working at the Dept
of Pediatric Orthopaedic Surgery at the Karolinska University Hospital.
Clinically, my main interests are cerebral palsy, arthrogryposis (AMC), limb
deficiencies, spina bifida (MMC), developmental dysplasia of the hip (DDH)
and trauma. My PhD from 2004 investigated tendon transfer mechanics and
properties of spastic muscle.

Research

Our main research focus is to explore dynamic adaptations of the muscle in
cerebral palsy on molecular, cellular and functional levels, with special
emphasis on the mechanisms of contracture formation and the influence of
treatments.
The group includes
Eva Pontén [1] MD PhD, orthopaedic surgeon and hand surgeon
Ferdinand von Walden [2], MD, PhD, post doc
Stefan Gantelius [3], MD, PhD student, orthopaedic surgeon
[1] https://ki.se/en/people/evapon
[2] https://ki.se/en/people/fervon
[3] https://ki.se/en/people/stegan

Articles

Article: BMC MUSCULOSKELETAL DISORDERS. 2024;25(1):803
Exploration of the triceps surae muscle in ambulatory children with cerebral palsy using instrumented measurements of stiffness and diffusion tensor magnetic resonance imaging for muscle architecture
Ahblom A; Ponten E; Destro A; Petersson S; von Walden F; Wang R; Lidbeck C
Journal article: GAIT & POSTURE. 2024;113:61-63
Symmetric gait with prosthetic and orthotic devices in children with congenital lower limb deficiencies
Eriksson M; Eliasson Å; Pontén E; Reimeringer M; Bartonek Å
Journal article: GAIT & POSTURE. 2024;113:240-241
Disproportional ventilatory response to acute incremental exercise in individuals with cerebral palsy
Corell L; Hjalmarsson E; Fernandez-Gonzalo R; Edman S; Kizyte A; Wang R; Kruse A; Pontén E; Norrbom J; Von Walden F
Journal article: GAIT & POSTURE. 2024;113:244-245
Spatial distribution of intramuscular fat in triceps surae in children with cerebral palsy
Wang Z; Xu C; Destro A; Petersson S; Pontén E; Lidbeck C; Wang R
Article: AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION. 2024;103(1):79-86
Determinants of Frame Running Capacity in Athletes With Cerebral Palsy to Improve Training Routines and Classification Strategies
Hjalmarsson E; Lidbeck C; Barrero Santiago L; Pingel J; Norrbom J; Sanz G; Palmcrantz A; Ponten E; von Walden F; Fernandez-Gonzalo R
Article: JOURNAL OF PEDIATRIC REHABILITATION MEDICINE. 2023;16(1):125-137
Time-matched accelerometers on limbs and waist in children with CP give new insights into real-life activities after botulinum toxin treatment: A proof of concept study
Gantelius S; Vikerfors S; Edqvist JJ; von Walden F; Hagstromer M; Ponten E
Article: PEDIATRIC PHYSICAL THERAPY. 2022;34(4):529-534
Physiological Response to the 6-Minute Frame Running Test in Children and Adults With Cerebral Palsy
Bos AMME; Hjalmarsson E; Dallmeijer AJ; Fernandez-Gonzalo R; Buizer AI; Pingel J; Ponten E; von Walden F; van Schie PEM
Journal article: GAIT & POSTURE. 2022;97:s364
Use of orthoses and prostheses, physical capacity and satisfaction with the devices in children with congenital lower limb deficiencies
Eliasson Å; Eriksson M; Pontén E; Bartonek Å
Article: FRONTIERS IN PHYSIOLOGY. 2022;13:1072040
Extracellular vesicle characteristics and microRNA content in cerebral palsy and typically developed individuals at rest and in response to aerobic exercise
Vechetti IJ; Norrbom J; Alkner B; Hjalmarsson E; Palmcrantz A; Ponten E; Pingel J; von Walden F; Fernandez-Gonzalo R
Article: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. 2021;63(10):1204-1212
Reduced mitochondrial DNA and OXPHOS protein content in skeletal muscle of children with cerebral palsy
von Walden F; Vechetti IJJ; Englund D; Figueiredo VC; Fernandez-Gonzalo R; Murach K; Pingel J; Mccarthy JJ; Stal P; Ponten E
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7S):325
Racerunning Training For 12 Weeks Improves Physical Fitness And Promotes Skeletal Muscle Hypertrophy In Adolescents And Young Adults With Cerebral Palsy
von Walden F; Hjalmarsson E; Fernandez-Gonzalo R; Palmcrantz A; Kvist O; Pontén E
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7S):475
Skeletal Muscle Size Is An Important Factor For Racerunning Performance In Individuals With Cerebral Palsy
Hjalmarsson E; Fernandez-Gonzalo R; Pingel J; Santiago LB; Palmcrantz A; Pontén E; von Walden F
Article: JOURNAL OF REHABILITATION MEDICINE. 2020;52(5):jrm00060-0
COMPARATIVE ANALYSIS OF POWER, WORK AND MUSCLE ACTIVATION DURING WEIGHT-STACK AND ISO-INERTIAL FLYWHEEL RESISTANCE EXERCISE IN YOUNG ADULTS WITH CEREBRAL PALSY
Von Walden F; Hjalmarsson E; Reimeringer M; Kvist O; Raffalt PC; Ponten E; Fernandez-Gonzalo R
Article: BMC MUSCULOSKELETAL DISORDERS. 2020;21(1):193
RaceRunning training improves stamina and promotes skeletal muscle hypertrophy in young individuals with cerebral palsy
Hjalmarsson E; Fernandez-Gonzalo R; Lidbeck C; Palmcrantz A; Jia A; Kvist O; Ponten E; von Walden F
Article: JOURNAL OF REHABILITATION MEDICINE. 2020;52(2):jrm00022-0
EFFECT OF ACUTE TRANSCRANIAL MAGNETIC STIMULATION ON INTRACELLULAR SIGNALLING IN HUMAN SKELETAL MUSCLE
von Walden F; Gidlund E-K; Liu C; Ramstrand N; Norrbom J; von Wachenfelt N; Kjellgren H; Sundberg CJ; Ponten E; Alkner B
Article: FRONTIERS IN PEDIATRICS. 2020;8:236
Epigenetic Marks at the Ribosomal DNA Promoter in Skeletal Muscle Are Negatively Associated With Degree of Impairment in Cerebral Palsy
von Walden F; Fernandez-Gonzalo R; Pingel J; McCarthy J; Stal P; Ponten E
Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS. 2019;181(3):288-299
International multidisciplinary collaboration toward an annotated definition of arthrogryposis multiplex congenita
Dahan-Oliel N; Cachecho S; Barnes D; Bedard T; Davison AM; Dieterich K; Donohoe M; Fafara A; Hamdy R; Hjartarson HT; Hoffman NS; Kimber E; Komolkin I; Lester R; Ponten E; van Bosse HJP; Hall JG
Journal article: JOURNAL OF PEDIATRIC ORTHOPAEDICS. 2019;39(7):E536-E541
Reliability of Radiographic Assessments of the Hip in Cerebral Palsy
Shore BJ; Martinkevich P; Riazi M; Baird E; Encisa C; Willoughby K; Narayanan UG
Article: JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B. 2019;28(4):301-308
Outcome of hand surgery in children with spasticity - a 9-year follow-up study
Ponten E; von Walden F; Lenke-Ekholm C; Zethraeus B-M; Eliasson A-C
Article: MUSCLE & NERVE. 2018;58(2):277-285
MUSCLE CONTRACTURES IN PATIENTS WITH CEREBRAL PALSY AND ACQUIRED BRAIN INJURY ARE ASSOCIATED WITH EXTRACELLULAR MATRIX EXPANSION, PRO-INFLAMMATORY GENE EXPRESSION, AND REDUCED rRNA SYNTHESIS
Von Walden F; Gantelius S; Liu C; Borgstrom H; Bjork L; Gremark O; Stal P; Nader GA; Ponten E
Article: BIOMECHANICS AND MODELING IN MECHANOBIOLOGY. 2017;16(6):1869-1883
Influence of muscle groups' activation on proximal femoral growth tendency
Yadav P; Shefelbine SJ; Ponten E; Gutierrez-Farewik EM
Article: JOURNAL OF PEDIATRIC ORTHOPAEDICS. 2017;37(5):S16-S23
Treatment of the Lower Extremity Contracture/Deformities
van Bosse HJP; Ponten E; Wada A; Agranovich OE; Kowalczyk B; Lebel E; Senaran H; Derevianko DV; Vavilov MA; Petrova EV; Barsukov DB; Batkin SF; Eylon S; Kenis VM; Stepanova YV; Buklaev DS; Yilmaz G; Kose O; Trofimova SI; Durgut F
Article: FRONTIERS IN COMPUTATIONAL NEUROSCIENCE. 2017;11:30
Forearm Flexor Muscles in Children with Cerebral Palsy Are Weak, Thin and Stiff
von Walden F; Jalaleddini K; Evertsson B; Friberg J; Valero-Cuevas FJ; Ponten E
Article: LAKARTIDNINGEN. 2016;113:DS6L
[Elbow injuries in children].
Rönnblad E; Wihlborg A; Wärle E; Pontén E
Article: BMC MUSCULOSKELETAL DISORDERS. 2015;16:384
Gait dynamics in the wide spectrum of children with arthrogryposis: a descriptive study
Eriksson M; Bartonek A; Ponten E; Gutierrez-Farewik EM
Article: BRAIN RESEARCH. 2015;1620:98-106
Activity in the brain network for dynamic manipulation of unstable objects is robust to acute tactile nerve block: An fMRI study
Pavlova E; Hedberg A; Ponten E; Gantelius S; Valero-Cueuas FJ; Forssberg H
Journal article: GAIT & POSTURE. 2015;42:s87-s88
Gait dynamics in the wide spectrum of children with arthrogryposis
Eriksson M; Bartonek Å; Pontén E; Gutierrez-Farewik EM
Journal article: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2015;167(6):1193-1195
Summary of the 2nd international symposium on arthrogryposis, St. Petersburg, Russia, September 17-19, 2014
Hall JG; Ogranovich A; Ponten A; van Bosse HJP
Journal article: GAIT & POSTURE. 2014;39:s54-s55
Variation in hip contact force during gait due to neck shaft angle and femoral anteversion
Yadav P; Pontén E; Gutierrez-Farewik EM
Journal article: CLINICAL NEUROPHYSIOLOGY. 2014;125:s98
LP13: Activity in the brain network for dynamic manipulation of unstable objects is robust to acute tactile deafferentation: an fMRI study
Pavlova E; Hedberg Å; Ponten E; Gantelius S; Valero-Cuevas F; Forssberg H
Journal article: GAIT & POSTURE. 2013;38(Neurorehabilitation and Neural Repair2572011):s32
The correlation between viscosity, elasticity and the cross-sectional area of wrist- and finger-flexor muscles—A study of the NeuroFlexor®
Pontén E; Evertsson B; Gäverth J
Journal article: GAIT & POSTURE. 2013;38:s18
Volumetric motion analysis – A simple and accurate way of measuring 3-dimensional reach in children
Gantelius S; Lennartsson A; Pontén E; Gutierrez-Farewik E
Journal article: GAIT & POSTURE. 2013;38:s38
Botulinum toxin injections in lower extremity changes activity in upper extremity in cerebral palsy—A case report
Gantelius S; Viklund A; Hagströmer M; Pontén E
Article: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 2012;470(5):1272-1277
Higher Expression of Myosin Heavy Chain IIx in Wrist Flexors in Cerebral Palsy
Gantelius S; Hedstrom Y; Ponten E
Article: JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B. 2011;20(6):359-365
Bimanuality is improved by hand surgery in children with brain lesions: preliminary results in 18 children
Ponten E; Ekholm CL; Eliasson A-C
Article: BMC MEDICAL GENOMICS. 2009;2:44
Novel transcriptional profile in wrist muscles from cerebral palsy patients
Smith LR; Ponten E; Hedstrom Y; Ward SR; Chambers HG; Subramaniam S; Lieber RL
Article: PHYSICAL & OCCUPATIONAL THERAPY IN PEDIATRICS. 2009;29(3):311-333
Feasibility of a Day-Camp Model of Modified Constraint-Induced Movement Therapy With and Without Botulinum Toxin A Injection for Children With Hemiplegia
Eliasson A-C; Shaw K; Ponten E; Boyd R; Krumlinde-Sundholm L
Article: LAKARTIDNINGEN. 2008;105(43):3009-3013
[Upper extremity botulinum toxin treatment in cerebral palsy. Treatment guidelines the first step towards national cooperation].
Arner M; Himmelmann K; Pontén E; Stankovic N; Hansson T; Dahlin LB
Article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2008;266(1-2):51-56
Higher amount of MyHC IIX in a wrist flexor in tetraplegic compared to hemiplegic cerebral palsy
Ponten E; Lindstrom M; Kadi F
Article: JOURNAL OF BIOMECHANICS. 2008;41(8):1801-1804
Immobilization of the rabbit tibialis anterior muscle in a lengthened position causes addition of sarcomeres in series and extra-cellular matrix proliferation
Ponten E; Friden J
Article: MUSCLE & NERVE. 2007;36(1):47-54
Intraoperative muscle measurements reveal a relationship between contracture formation and muscle remodeling
Ponten E; Gantelius S; Lieber RL
Article: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2007;253(1-2):25-33
Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis
Ponten EM; Stal PS
Journal article: GAIT & POSTURE. 2006;24:s39-s40
Towards a new protocol for motion analysis of the upper extremities in hemiplegic cerebral palsy
Gutierrez-Farewik E; Munaretto J; Pontén E
Article: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. 2005;47(6):384-389
Spastic wrist flexors are more severely affected than wrist extensors in children with cerebral palsy
Pontén E; Fridén J; Thornell LE; Lieber RL
Journal article: JOURNAL OF HAND SURGERY-AMERICAN VOLUME. 2003;28:60
Structure in flexor versus extensor upper limb muscles in cerebral palsy
Pontén E; Thornell L-E; Fridén J
Article: JOURNAL OF HAND SURGERY-AMERICAN VOLUME. 2000;25A(1):138-143
Effect of muscle tension during tendon transfer on sarcomerogenesis in a rabbit model
Fridén J; Pontén E; Lieber RL
Article: JOURNAL OF HAND SURGERY-AMERICAN VOLUME. 1996;21A(4):612-618
Sarcomere length changes after flexor carpi ulnaris to extensor digitorum communis tendon transfer
Lieber RL; Ponten E; Burkholder TJ; Friden J
Journal article: DIABETE ET METABOLISME. 1983;9(2):106-111
STUDY OF ISOLATED-MITOCHONDRIA INCUBATED WITH LABELED AND NON-LABELED ALLOXAN, WITH REGARD TO INTRAMITOCHONDRIAL CONCENTRATIONS OF REDUCED GLUTATHIONE AND INORGANIC-PHOSPHATE
BOQUIST L; PONTEN E; SANDSTROM E
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All other publications

Conference publication: ACTA PHYSIOLOGICA. 2023;239
Individuals with cerebral palsy have an altered ventilatory response to acute incremental exercise
Corell L; Hjalmarsson E; Fernandez-Gonzalo R; Norrbom J; Kruse A; Ponten E; von Walden F
Conference publication: ACTA PHYSIOLOGICA. 2023;239
Children with cerebral palsy exhibit reduced skeletal muscle respiratory capacity
Edman S; Corell L; Lanner JT; Ponten E; von Walden F
Conference publication: ACTA PHYSIOLOGICA. 2023;239
Validation of the 6-minute frame running test as a cardiopulmonary maximal test in cerebral palsy
Corell L; Hjalmarsson E; Bos AE; Kruse A; Fernandez-Gonzalo R; Norrbom J; Ponten E; van Schie P; Buizer AI; von Walden F
Book chapter: CONGENITAL AND ACQUIRED DEFORMITIES OF THE PEDIATRIC SHOULDER GIRDLE. 2022;p. 219-223
The Shoulder Girdle in Cerebral Palsy
Pontén E
Review: JOURNAL OF CHILDRENS ORTHOPAEDICS. 2021;15(2):89-96
Current concepts in diagnosis and management of common upper limb nerve injuries in children
Catena N; Di Gennaro GL; Jester A; Martinez-Alvarez S; Ponten E; Soldado F; Steiger C; Choong J; Zarantonello P; Farr S
Editorial comment: FRONTIERS IN PHYSIOLOGY. 2021;12:802202
Muscle Mechanics, Extracellular Matrix, Afferentation, Structural, and Neurological Coupling and Coordination in Health and Disease
Yucesoy CA; Ponten E; Valero-Cuevas FJ; Smeulders M; Simms CK
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7):325
Racerunning Training For 12 Weeks Improves Physical Fitness And Promotes Skeletal Muscle Hypertrophy In Adolescents And Young Adults With Cerebral Palsy
von Walden F; Hjalmarsson E; Fernandez-Gonzalo R; Palmcrantz A; Kvist O; Ponten E
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7):475
Skeletal Muscle Size Is An Important Factor For Racerunning Performance In Individuals With Cerebral Palsy
Hjalmarsson E; Fernandez-Gonzalo R; Pingel J; Santiago LB; Palmcrantz A; Ponten E; von Walden F
Editorial comment: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. 2019;61(2):117-118
Contracture formation in the upper limb in cerebral palsy starts early
Ponten E
Editorial comment: JOURNAL OF PEDIATRIC ORTHOPAEDICS. 2017;37(5):S2-S3
Background to the 2nd International Symposium on Arthrogryposis
Lester R; Hall JG; Ponten E; van Bosse HJP
Review: JOURNAL OF CHILDRENS ORTHOPAEDICS. 2015;9(6):465-472
Management of the knees in arthrogryposis
Ponten E
Corrigendum: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2015;167(11):2866
Summary of the 2nd International Symposium on Arthrogryposis, St. Petersburg, Russia, September 17-19, 2014 (vol 167, pg 1193, 2015)
Hall JG; Agranovich O; Ponten E; van Bosse HJP
Book chapter: EUROPEAN SURGICAL ORTHOPAEDICS AND TRAUMATOLOGY. 2014;p. 4609-4626
Orthopaedic Management of CP/Myelomeningocele - Upper Limb
Pontén E

Employments

Affiliated to Research, Department of Women's and Children's Health, Karolinska Institutet, 2022-2025

Degrees and Education

Docent, Karolinska Institutet, 2019

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